Tetrasulfonated diphosphine compounds and metal complexes thereof for asymmetric catalytic reactions
AssigneeHoffmann-La Roche Inc.
InventorsMichel Lalonde, Rudolf Schmid
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Abstract
The invention is concerned with novel water-soluble racemic or optically active compounds of formulae ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently signify lower alkyl or lower alkoxy; m and n are 0, 1 or 2; and X signifies hydrogen, an alkali :metal, the equivalent of an earth alkali metal or an ammonium ion; with the provision that R.sup.3 is in position 4 or 5 and R.sup.4 is in position 4' or 5'. The invention is also concerned with complexes of such compounds with a metal of Group VIII. These complexes are, useful as catalysts for asymmetric hydrogenation and for enantioselective hydrogen displacement in prochiral allylic systems.
Claims19
Water-soluble racemic or optically active compound of the formulae ##STR11## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently are lower alkyl or lower alkoxy;
- m and n are 0, 1 or 2;
- X is hydrogen, an alkali metal, earth alkali metal or an ammonium ion;
- R.sup.3 is in position 4 or 5;
- and R.sup.4 is in position 4' or 5'.
The compound (R,S)-, (R)- or (S)-6,6'-dimethoxy-biphenyl-2,2'-bis(4,4'phosphinediyldibenzenesulfonic acid) Na salt (1:4).
The compound ((S)-6,6'-Dimethoxy-biphenyl-2,2'-bis(4,4'-phosphinediyl-dibenzenesulfonic acid)Na salt) ruthenium (OCOF.sub.3).sub.2.
The compound [((S)-6,6'-Dimethoxy-biphenyl-2,2'-bis(4,4'-phosphine-diyl-dibenzenesulfon ic acid)Na salt) rhodium (1.5-cyclooctadiene)]BF.sub.4.
The compound [((S)-6,6'-Dimethoxy-biphenyl-2,2'-bis (4,4'-phosphinediyl-dibenzene sulfonic acid)Na salt) rhodium (norbornadiene)]BF.sub.4.
The compound [((S)-6,6'-Dimethoxy-biphenyl-2,2'bis(4,4'-phosphinediyl-dibenzenesulfonic acid)Na salt) rhodium (norbornadiene)]Cl.
Dependencies are inferred from the claim text.