Integrin-binding peptides
AssigneeLa Jolla Cancer Research Foundation
InventorsErkki Ruoslahti, Erkki Koivunen
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Abstract
The present invention provides peptides having specificity for fibronectin-binding and vitronectin-binding integrins, and in particular for .alpha..sub.5 .beta..sub.1 integrin. These peptides are characterized by having the ability to interfere with extracellular matrix protein binding to integrins; to block attachment of cells expressing these integrins to extracellular matrix proteins; and to promote cell attachment when coated onto a surface.
Claims2
A purified synthetic peptide consisting of the amino acid sequence CRGDCL (SEQ ID NO 1).
A purified synthetic peptide consisting of an amino acid sequence selected from the group consisting of:
- CRGDCA (SEQ ID NO 26);
- GACRGDCLGA (SEQ ID NO 3);
- CVLNGRME (SEQ ID NO 13);
- NGRAHA (SEQ ID NO 4);
- DGRAHA (SEQ ID NO 11) and
- ALNGREESP (SEQ ID NO 6).
Dependencies are inferred from the claim text.