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US 5,536,507 AGranted
Colonic drug delivery system
AssigneeBristol-Myers Squibb Company
InventorsRobert Abramowitz, Sunanda A. Ranadive, Sailesh A. Varia, Nemichand B. Jain
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Abstract
A three component pharmaceutical formulation of one or more pharmacologically active substances such that greater than 80% of the pharmacologically active substance will be released in the large intestine. The first component comprises the pharmacologically active substance, microcrystalline cellulose, a pH-sensitive polymer, and optionally an osmotic agent. The second component is a delayed release coating, and the third component is an enteric coating.
Claims15
A three component pharmaceutical formulation comprising:
- a first component which includes at least one pharmacologically active substance, microcrystalline cellulose, a pH-sensitive polymer which is a carbomer or a sodium salt of a carbomer, and optionally an osmotic agent;
- a second component which is a delayed release coating wherein said delayed release coating includes a non-water soluble polymer, a plasticizer and an antiagglomerating agent;
- and a third component which is an enteric coating.
Dependencies are inferred from the claim text.