US 5,534,640 A · 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds

Abstract

Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth are disclosed.

Claims4

Dependent claims

A compound of the formula

wherein R.sup.5 is CH.sub.3 (CH.sub.2).sub.m C.XI.C, or ##STR62## wherein m is 3 to 15, n is 0 to 12, and W and X are independently hydrogen, hydroxy, loweralkyl, loweralkoxy, halogen, trifluoromethyl or ##STR63## wherein R.sup.23 is loweralkyl, with proviso that X is not hydrogen or lower alkyl when the compounds are ##STR64## .

Dependencies are inferred from the claim text.

Facts

Application

08/426,755Filed 21 Apr 1995 · division

Priority

13 Mar 1990

Granted

9 Jul 1996

Term ends

Not estimatedThe source records don’t support an estimate.

Classification18 codes

C07D 213/40
Radicals substituted by singly-bound nitrogen atoms: acylated substituent nitrogen atom
C07C 45/68
By isomerisation; by change of size of the carbon skeleton: by increase in the number of carbon atoms
C07C 47/542
Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings: alkylated benzaldehydes
C07C 215/36
Containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton and at least one…:…

Family

Serial492,200Parent of this continuation-in-part · filed 13 Mar 1990

Serial596,448Parent of this continuation-in-part · filed 12 Oct 1990

Serial632,910Parent of this continuation · filed 24 Dec 1990

Serial840,236Parent of this continuation-in-part · filed 24 Feb 1992

Serial942,908Parent of this division · filed 10 Sep 1992

US 5,360,811 AParent of this division

US 5,534,640 AThis patent

From the US filing history. Foreign family members aren’t listed.

Abstract

Claims4

Dependent claims

A compound of the formula

wherein R.sup.5 is CH.sub.3 (CH.sub.2).sub.m C.XI.C, or ##STR62## wherein m is 3 to 15, n is 0 to 12, and W and X are independently hydrogen, hydroxy, loweralkyl, loweralkoxy, halogen, trifluoromethyl or ##STR63## wherein R.sup.23 is loweralkyl, with proviso that X is not hydrogen or lower alkyl when the compounds are ##STR64## .

Dependencies are inferred from the claim text.

Facts

Application

08/426,755Filed 21 Apr 1995 · division

Priority

13 Mar 1990

Granted

9 Jul 1996

Term ends

Not estimatedThe source records don’t support an estimate.

Classification18 codes

C07D 213/40
Radicals substituted by singly-bound nitrogen atoms: acylated substituent nitrogen atom
C07C 45/68
By isomerisation; by change of size of the carbon skeleton: by increase in the number of carbon atoms
C07C 47/542
Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings: alkylated benzaldehydes
C07C 215/36
Containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton and at least one…:…

Family

Serial492,200Parent of this continuation-in-part · filed 13 Mar 1990

Serial596,448Parent of this continuation-in-part · filed 12 Oct 1990

Serial632,910Parent of this continuation · filed 24 Dec 1990

Serial840,236Parent of this continuation-in-part · filed 24 Feb 1992

Serial942,908Parent of this division · filed 10 Sep 1992

US 5,360,811 AParent of this division

US 5,534,640 AThis patent

From the US filing history. Foreign family members aren’t listed.

1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds

Life of this patent

Abstract

Claims4

1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds

Life of this patent

Abstract

Claims4