Particles, method of preparing said particles and uses thereof
AssigneeGS Biochem AB
InventorsTomas Landh, Kare Larsson
Life of this patent
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Abstract
Particles, especially colloidal particles, comprising an interior phase of a non-lamellar reversed cubic, intermediate or hexagonal liquid crystalline phase, or a homogeneous L3 phase, and a surface phase of a lamellar crystalline or liquid crystalline phase, or an L3 phase. A method of preparing such particles by creating a local dispersible phase, within the homogeneous phase, preferably by means of a fragmentation agent, and fragmentating the homogeneous phase so as to form said surface phase. Several medical as well as non-medical uses of the particles referred to, e.g. as an antigen-presenting system, as a delivery system for anticancer, antifungal and antimicrobial drugs, and as carriers of nucleic acids or nucleotides.
Claims35
Particles comprising
- (A) an interior phase of (1) a non-lamellar lyotropic liquid crystalline phase selected from the group consisting of a reversed cubic liquid crystalline phase and a reversed hexagonal liquid crystalline phase, or (2) a homogeneous L3 phase, or any combination thereof, and
- (B) a surface phase (1) selected from the group consisting of a lamellar crystalline phase and a lamellar liquid crystalline phase, or (2) an L3 phase, or any combination thereof
- wherein said surface phase and said interior phase are distinct.
A method of preparing particles from a homogeneous liquid crystalline phase or L3 phase, which comprises forming a homogeneous, non-lamellar lyotropic liquid crystalline phase selected from the group consisting of a reversed cubic liquid crystalline phase and a reversed hexagonal liquid crystalline phase, or a homogeneous L3 phase, or any combination thereof, creating a local dispersible phase, within said homogeneous phase, of a phase selected from the group consisting of a lamellar crystalline phase and a lamellar liquid crystalline phase, or an L3 phase, or any combination thereof, in the presence of a solvent phase, said solvent being of a nature with which said homogeneous phase can coexist and wherein said dispersible phase can be dispersed, and fragmentating said homogeneous phase so as to form particles, the interior phase of which comprises said homogeneous phase and the surface phase of which comprises said dispersible phase.
Dependencies are inferred from the claim text.