Back to results
US 5,527,924 AGranted
Total synthesis of taxol
AssigneeSloan-Kettering Institute for Cancer Research
InventorsSamuel J. Danishefsky, William G. Bornmann, Yves Queneau, Thomas V. Magee, Walter J. Krol
Life of this patent
Estimating the term…
Abstract
The present invention provides two basic routes for the total synthesis of taxol having the structure: ##STR1## The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogs to taxol. Both the intermediates and analogs to taxol may prove to be valuable anticancer agents.
Claims1
A compound having the structure:
- ##STR218## wherein X.sub.3 and X.sub.4 are independently the same or different and are H, OR, O, --OCH.sub.2 CH.sub.2 O--, or --SCH.sub.2 CH.sub.2 CH.sub.2 S--;
- and R.sub.2 and R.sub.3 are independently the same or different and are H, acyl, alkyl, aryl, TBS, TES, TMS, or TBDPS;
- wherein R is H, acyl, alkyl, aryl, TBS, TES, TMS, or TBDPS.
Dependencies are inferred from the claim text.