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US 5,527,893 AGranted
Water insoluble derivatives of polyanionic polysaccharides
AssigneeGenzyme Corporation
InventorsJames W. Burns, Robert Miller, Alan E. Walts
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Abstract
A water insoluble, biocompatible composition composed of an acyl derivative of a polyanionic polysaccharide, a carbodiimide, and optionally, a nucleophile.
Claims8
A method of making a water insoluble biocompatible composition comprising an acyl urea derivative of hyaluronic acid, said method consisting essentially of
- providing said hyaluronic acid in an aqueous solution, and
- reacting said hyaluronic acid with a carbodiimide in said aqueous solution under conditions sufficient to produce said composition, wherein the reaction is carried out at a pH of 3.5 to 8.0.
A water insoluble biocompatible composition consisting essentially of the reaction product of an acyl urea derivative of hyaluronic acid and a carbodiimide.
Dependencies are inferred from the claim text.