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US 5,525,735 AGranted
Methods for synthesizing diverse collections of pyrrolidine compounds
AssigneeAffymax Technologies N.V.
InventorsMark A. Gallop, Martin A. Murphy
Life of this patent
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Abstract
Disclosed are methods for synthesizing very large collections of diverse pyrrolidine compounds and derivatives thereof on solid supports and synthetic compound libraries comprising pyrrolidine groups and derivatives thereof prepared by such methods.
Claims9
A synthetic compound library comprising a plurality of different compounds each compound covalently linked to a solid support wherein each of said compounds comprise at least one pyrrolidinyl group which group is prepared by the method which comprises
- (a) selecting a solid support comprising at least one compound attached thereto which compound comprises a moiety selected from the group consisting of a complementary group having at least one site of carbon-carbon unsaturation and an azomethine ylide precursor;
- and
- (b) converting said moiety to a pyrrolidinyl group.
Dependencies are inferred from the claim text.