Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsLarry K. Keefer, Joseph A. Hrabie, Joseph E. Saavedra
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Abstract
A polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group bound to the polymer; pharmaceutical compositions including the polymeric composition; and methods for treating biological disorders in which dosage with nitric oxide is beneficial. The compositions can be used as and/or incorporated into implants, injectables, condoms, prosthesis coatings, patches, and the like for use in a wide variety of medical applications.
Claims27
A polymeric composition capable of releasing nitric oxide, said composition comprising the admixture of a polymer selected from the group consisting of a poly (lactide/glycolide) and a polyethylene glycol;
- and a compound having a nitric oxide releasing N.sub.2 O.sub.2 functional group, said compound having the structure X--N(O)NO] or [N(O)NO--X, wherein X is a moiety bonded to said N.sub.2 O.sub.2 group.
Dependencies are inferred from the claim text.