Coating compositions comprising pharmaceutical agents
AssigneeSTS Biopolymers, Inc.
InventorsRichard J. Whitbourne, Margaret A. Mangan
Life of this patent
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Abstract
Anti-thrombogenic, and/or anti-microbial and/or pharmaceutical compositions containing heparin and/or antibiotics and/or other pharmaceutical agents which may be reacted with quaternary ammonium components or other ionic surfactants and bound with water-insoluble polymers are disclosed. Such compositions may also contain additional quaternary ammonium compounds or other ionic surfactants not reacted with heparin and may also contain quaternary ammonium compound(s) or other ionic surfactants reacted with antibiotics or other ionic or nonionic pharmaceutical agents.
Claims46
A device comprising:
- a substrate, and a coating composition comprising a pharmaceutical agent in a concentration of from about 0.5% to about 99.5% by weight and a water-insoluble cellulose ester polymer, the coating composition being resistant to removal and having pharmaceutical activity under physiological conditions.
A coated device produced by a process comprising:
- (a) combining a pharmaceutical agent in a concentration of from about 0.01% to about 40%, a water-insoluble cellulose ester polymer in a concentration of from about 0.01% to about 40%, and an organic solvent to form a coating liquid,
- (b) placing a device in contact with the coating liquid,
- (c) removing the device from the coating liquid, and
- (d) removing the organic solvent to form a coating on the device, wherein the coating adheres to the device and has pharmaceutical activity under physiological conditions.
A coated article produced by a process comprising:
- preparing a polymer coating liquid comprising a water-insoluble cellulose ester polymer in a concentration of from about 0.01% to about 40%, and an organic solvent for the polymer,
- preparing a pharmaceutical coating liquid comprising a pharmaceutical agent in a concentration of from about 0.01% to about 40%, and an organic liquid,
- contacting an article with the polymer coating liquid, removing the article, and removing the organic solvent, and
- contacting the article with the pharmaceutical coating liquid, removing the article, and removing the organic liquid, to produce a coated article having an adherent, essentially water-insoluble coating with pharmaceutical activity under physiological conditions.
A coated article comprising:
- a substrate;
- and
- a coating comprising a pharmaceutical agent in a concentration of from about 0.5% to about 99.5% by weight, and a water-insoluble cellulose ester polymer, the pharmaceutical agent being entrained in the cellulose ester polymer in such a way as to be gradually released under physiological conditions, to provide effective concentrations of the pharmaceutical agent at the surface of the coating over a useful period, and the coating being adherent to the substrate and essentially water-insoluble.
Dependencies are inferred from the claim text.