N-methyldeacetylcolchiceinamide derivatives
AssigneeOhgen Research Laboratories, Ltd.
InventorKiyoshi Akiyama
Life of this patent
Estimating the term…
Abstract
N-methyldeacetylcolchiceinamide derivatives represented by the formula ##STR1## wherein R denotes a residue obtained by removing COOH from a C.sub.3 -C.sub.7 sugar carboxylic acid, and hydroxyl groups present in the residue may properly be protected with a protecting group for a hydroxyl group. The N-methyldeacetylcolchiceinamide derivatives have less toxicity and strong effect for inhibiting proliferation of tumor cells, and are expected to be used as a carcinostatic.
Claims5
A N-methyldeacetylcolchiceinamide derivative represented by the following formula or a salt thereof:
- ##STR17## wherein R denotes a residue obtained by removing COOH from a carboxylic acid selected from the group consisting of glyceric acid, ribose carboxylic acid, glucuronic acid, gluconic acid and glucoheptanoic acid, and hydroxyl groups present in the residue are unprotected or protected with a hydroxyl-protecting group.
N'-(O,O-isopropylideneglyceroyl)-N-methyldeacetylcolchiceinamide.
Dependencies are inferred from the claim text.