Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists

A compound of Formula I:

• ##STR42## or a pharmaceutically acceptable salt form thereof, wherein:
• W is piperazinyl;
• Y is selected from O, S, or a single bond;
• L.sup.1 is a bond;
• L.sup.2 is selected from:
• --CH.dbd.CH-- substituted with 0-2 R.sup.5b ;
• or
• --(cyclopropyl)--substituted with 0-1 R.sup.5b ;
• Z is --C(.dbd.O)--;
• X is selected from O or a single bond;
• A is selected from CO.sub.2 R.sup.9 ;
• R.sup.1 and R.sup.2 are independently selected from:
• H,
• C.sub.1 to C.sub.8 alkyl substituted with 0-2 R.sup.5,
• C.sub.2 to C.sub.8 alkenyl substituted with 0-2 R.sup.5,
• C.sub.4 to C.sub.8 cycloalkylmethyl,
• OR.sup.5a ;
• R.sup.3 and R.sup.4 are independently selected from:
• H,
• C.sub.1 to C.sub.6 alkyl substituted with 0-2 R.sup.5,
• I, F, Br, Cl, CO.sub.2 R.sup.5a, OR.sup.5a, OCH.sub.2 CO.sub.2 R.sup.5a, CO.sub.2 CH.sub.2 CO.sub.2 R.sup.5a, or NO.sub.2 ;
• R.sup.5, R.sup.7, R.sup.5a, and R.sup.5b are independently selected from H, C.sub.1 to C.sub.6 straight or branched alkyl, C.sub.2 to C.sub.6 alkenyl, C.sub.4 to C.sub.7 cycloalkylmethyl, or C.sub.7 to C.sub.11 arylalkyl;
• R.sup.9 is selected from H, C.sub.1 to C.sub.4 alkyl, C.sub.3 to C.sub.10 alkylcarbonyloxyalkyl, C.sub.3 to C.sub.10 alkoxycarbonyloxyalkyl, C.sub.2 to C.sub.10 alkoxycarbonyl, C.sub.5 to C.sub.10 cycloalkylcarbonyloxyalkyl, C.sub.5 to C.sub.10 cycloalkoxycarbonyloxyalkyl, C.sub.5 to C.sub.10 cycloalkoxycarbonyl, C.sub.7 to C.sub.11 aryloxycarbonyl, C.sub.8 to C.sub.12 aryloxycarbonyloxyalkyl, C.sub.8 to C.sub.12 arylcarbonyloxyalkyl, C.sub.5 to C.sub.10 alkoxyalkylcarbonyloxyalkyl, C.sub.5 to C.sub.10 (5-alkyl-1,3-dioxa-cyclopenten-2-one-yl)methyl, (5-phenyl-1,3-dioxa-cyclopenten-2-one-yl) methyl, or (5-naphthyl-1,3-dioxa-cyclopenten-2-one-yl)methyl;
• m is selected from 1 or 2;
• and
• n is an integer from 1 to 3.