Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (BPI) protein product and antibiotic
AssigneeXoma Corporation
InventorsJonathan Cohen, Ada H. C. Kung, Lewis H. Lambert, Jr., Roger G. Little, II
Life of this patent
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Abstract
The present invention relates to methods and compositions for treating gram-negative bacterial infections, using BPI protein products. Co-treatment, or concurrent administration, of BPI protein product with an antibiotic in treatment of gram-negative bacterial infections improves the therapeutic effectiveness of the antibiotic, including increasing antibiotic susceptibility of gram-negative bacteria and reversing resistance of the bacteria to antibiotics.
Claims37
In a method for enhancing the effect of antibiotic treatment of a patient infected with gram-negative bacteria by concurrently administering bactericidal/permeability-increasing (BPI) protein and an antibiotic, the improvement comprising concurrently administering BPI protein product and polymyxin B in the treatment of a patient infected with a gram-negative bacteria selected from the group consisting of Escherichia, Providencia, and Pseudomonas species.
In a method for enhancing the effect of antibiotic treatment of a patient infected with gram-negative bacteria by concurrently administering bactericidal/permeability-increasing (BPI) protein and an antibiotic, the improvement comprising concurrently administering BPI protein product and ciprofloxacin in the treatment of a patient infected with a gram-negative bacteria selected from the group consisting of Pseudomonas, Enterobacter, and Acinetobacter species.
In a method for enhancing the effect of antibiotic treatment of a patient infected with gram-negative bacteria by concurrently administering bactericidal/permeability-increasing (BPI) protein and an antibiotic, the improvement comprising concurrently administering BPI protein product and ofloxacin in the treatment of a patient infected with a gram-negative bacteria selected from the group consisting of Pseudomonas and Acinetobacter species.
In a method for enhancing the effect of antibiotic treatment of a patient infected with gram-negative bacteria by concurrently administering bactericidal/permeability-increasing (BPI) protein and an antibiotic, the improvement comprising concurrently administering BPI protein product and aztreonam in the treatment of a patient infected with a gram-negative bacteria selected from the group consisting of Pseudomonas, Citrobacter, Enterobacter and Acinetobacter species.
In a method for enhancing the effect of antibiotic treatment of a patient infected with gram-negative bacteria by concurrently administering bactericidal/permeability-increasing (BPI) protein and an antibiotic, the improvement comprising concurrently administering BPI protein product and imipenem in the treatment of a patient infected with a gram-negative bacteria selected from the group consisting of Enterobacter, Proteus, Providencia and Acinetobacter species.
In a method for enhancing the effect of antibiotic treatment of a patient infected with gram-negative bacteria by concurrently administering bactericidal/permeability-increasing (BPI) protein and an antibiotic, the improvement comprising concurrently administering BPI protein product and gentamicin in the treatment of a patient infected with a gram-negative bacteria selected from the group consisting of Escherichia, Klebsiella, Edwardsiella, Salmonella, Pseudotnonas and Acinetobacter species.
In a method for enhancing the effect of antibiotic treatment of a patient infected with gram-negative bacteria by concurrently administering bactericidal/permeability-increasing (BPI) protein and an antibiotic, the improvement comprising concurrently administering BPI protein product and amikacin in the treatment of a patient infected with a gram-negative bacteria selected from the group consisting of Pseudomonas, Xanthamonas, Escherichia, Proteus, Providencia, Morganella and Acinetobacter species.
In a method for enhancing the effect of antibiotic treatment of a patient infected with gram-negative bacteria by concurrently administering bactericidal/permeability-increasing (BPI) protein and an antibiotic, the improvement comprising concurrently administering BPI protein product and tobramycin in the treatment of a patient infected with a gram-negative bacteria selected from the group consisting of Pseudomonas, Citrobacter, Serratia, Proteus and Acinetobacter species.
In a method for enhancing the effect of antibiotic treatment of a patient infected with gram-negative bacteria by concurrently administering bactericidal/permeability-increasing (BPI) protein and an antibiotic, the improvement comprising concurrently administering BPI protein product and netilmicin in the treatment of a patient infected with a gram-negative bacteria selected from the group consisting of Acinetobacter species.
In a method for enhancing the effect of antibiotic treatment of a patient infected with gram-negative bacteria by concurrently administering bactericidal/permeability-increasing (BPI) protein and an antibiotic, the improvement comprising concurrently administering BPI protein product and trimethoprim/sulfamethoxazole in the treatment of a patient infected with a gram-negative bacteria selected from the group consisting of Pseudomonas, Xanthamonas, Klebsiella, Enterobacter, Proteus and Acinetobacter species.
In a method for enhancing the effect of antibiotic treatment of a patient infected with gram-negative bacteria by concurrently administering bactericidal/permeability-increasing (BPI) protein and an antibiotic, the improvement comprising concurrently administering BPI protein product and chloramphenicol in the treatment of a patient infected with a gram-negative bacteria selected from the group consisting of Enterobacter and Acinetobacter species.
A method of treating a gram-negative bacterial infection in a subject comprising administering a BPI protein product and an antibiotic in synergistically effective amounts, wherein the antibiotic is selected from the group consisting of gentamicin, polymyxin B, cefamandole and ceftriaxone.
A method of killing gram-negative bacteria comprising administering a BPI protein product and an antibiotic in synergistically effective amounts, wherein the antibiotic is selected from the group consisting of gentamicin, polymyxin B, cefamandole and ceftriaxone.
A pharmaceutical composition for treatment of gram-negative bacterial infection comprising a BPI protein product and an antibiotic in synergistically effective amounts, wherein the antibiotic is selected from the group consisting of gentamicin, polymyxin B, cefamandole and ceftriaxone.
In a method for treating a patient infected with a Pseudomonas gram-negative bacterial species that is resistant to an antibiotic selected from the group consisting of amikacin, aztreonam, cefazolin, cefoxitin, ceftriaxone, cefuroxime, ofloxacin, piperacillin and ticarcillin, the improvement comprising the step of concurrently administering the antibiotic and an amount of BPI protein product effective to reverse the resistance of the gram-negative bacterial species to the antibiotic.
In a method for treating a patient infected with a Xanthamonas gram-negative bacterial species that is resistant to an antibiotic selected from the group consisting of amikacin, piperacillin and trimethoprim/sulfamethoxazole, the improvement comprising the step of concurrently administering the antibiotic and an amount of BPI protein product effective to reverse the resistance of the gram-negative bacterial species to the antibiotic.
In a method for treating a patient infected with a Escherichia gram-negative bacterial species that is resistant to an antibiotic selected from the group consisting of cefazolin and ceftriaxone, the improvement comprising the step of concurrently administering the antibiotic and an amount of BPI protein product effective to reverse the resistance of the gram-negative bacterial species to the antibiotic.
In a method for treating a patient infected with a Klebsiella gram-negative bacterial species that is resistant to an antibiotic selected from the group consisting of trimethoprim/suifamethoxazole and ceftriaxone, the improvement comprising the step of concurrently administering the antibiotic and an amount of BPI protein product effective to reverse the resistance of the gram-negative bacterial species to the antibiotic.
In a method for treating a patient infected with a Citrobacter gram-negative bacterial species that is resistant to ceftriaxone antibiotic, the improvement comprising the step of concurrently administering the antibiotic and an amount of BPI protein product effective to reverse the resistance of the gram-negative bacterial species to the antibiotic.
In a method for treating a patient infected with a Enterobacter gram-negative bacterial species that is resistant to an antibiotic selected from the group consisting of ampicillin, aztreonam, cefotaxime, ceftazidime, ceftriaxone, cefuroxime, piperacillin, ticarcillin, azlocillin, carbenicillin, cefamandole and cefonicid, the improvement comprising the step of concurrently administering the antibiotic and an amount of BPI protein product effective to reverse the resistance of the gram-negative bacterial species to the antibiotic.
In a method for treating a patient infected with a Serratia gram-negative bacterial species that is resistant to an antibiotic selected from the group consisting of cefotaxime and ceftazidime, the improvement comprising the step of concurrently administering the antibiotic and an amount of BPI protein product effective to reverse the resistance of the gram-negative bacterial species to the antibiotic.
In a method for treating a patient infected with a Providencia gram-negative bacterial species that is resistant to an antibiotic selected from the group consisting of cefazolin and cefuroxime, the improvement comprising the step of concurrently administering the antibiotic and an amount of BPI protein product effective to reverse the resistance of the gram-negative bacterial species to the antibiotic.
In a method for treating a patient infected with a Acinetobacter gram-negative bacterial species that is resistant to an antibiotic selected from the group consisting of amikacin, ampicillin, aztreonam, cefazolin, cefotaxime, cefoxitin, cefiazidime, ceftriaxone, cefuroxime, ciprofloxacin, gentamicin, piperacillin, ticarcillin, trimethoprim/sulfamethoxazole, amoxicillin, carbenicillin, cefamandole, cefonicid, cefoperazone, cefotetan, ceftizoxime, chloramphenicol, mezlocillin and netilmicin, the improvement comprising the step of concurrently administering the antibiotic and an amount of BPI protein product effective to reverse the resistance of the gram-negative bacterial species to the antibiotic.
Dependencies are inferred from the claim text.