Biodegradable controlled release flash flow melt-spun delivery system
AssigneeFuisz Technologies Ltd.
InventorRichard C. Fuisz
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Abstract
Biodegradable controlled release delivery systems using melt-spun biodegradable polymers as carriers for bio-effecting agents such as pharmaceutical actives are disclosed. Oral dosage forms as well as implants are described.
Claims28
A biodegradable controlled release composition comprising a non-saccharide biodegradable polymer united with a bio-effecting agent formed by flash-flow melt-spin processing said polymer and said bio-effecting agent.
A controlled release flash-flow melt-spun composition comprising:
- (a) a non-saccharide biodegradable polymer for physically protecting an active agent past the stomach and releasing the active agent in the small intestine;
- and
- (b) a bio-effecting agent united with said polymer.
A controlled release flash flow melt-spun composition for treatment of ruminants comprising:
- a) a non-saccharide biodegradable polymer which is protective of an active in the environment of the rumen at pH of about 5 or more but which releases the active in environment of the abomasum at pH of about 3.5 or less;
- and b) a bio-effecting active united with said polymer.
A method of treating an animal comprising administering to said animal a flash flow melt-spun controlled release composition comprising a non-saccharide biodegradable polymer and a bio-effecting therapeutic or prophylactic active.
A flash-flow melt-spun drug delivery system capable of controllably releasing a pharmaceutically active agent in an animal comprising a non-saccharide biodegradable polymer and a pharmaceutically active agent wherein the polymer is in predominantly amorphous form and is united with said active agent.
A method of preparing a controlled release pharmaceutical composition comprising subjecting a mixture of a biodegradable non-saccharide polymer and a pharmaceutically active agent to flash-flow melt-spinning to unite said polymer and active under conditions which produce a solid capable of releasing said active in an animal.
A device for promoting the growth of living tissue comprising a biocompatable or implantable support structure impregnated or coated with a biodegradable controlled release flash-flow melt-spun composition comprising a non-saccharide biodegradable polymer united with a growth regulator.
A method of making a device for promoting the growth of living tissue comprising (i) flash-flow melt-spinning a composition comprising a non-saccharide biodegradable polymer and a growth regulator and (ii) collecting said composition on a support structure.
A sustained release solid composition formed by flash-flow melt-spin processing a solid non-saccharide biodegradable polymer and a solid bio-effecting agent.
Dependencies are inferred from the claim text.