Loading patent…
AssigneeUniversity of Utah Research Foundation
InventorsRaymond A. Daynes, Barbara A. Araneo
Estimating the term…
The invention relates to a vaccine which comprises an antigen and a lymphoid organ modifying agent. Suitable lymphoid organ modifying agents include 1,25-dihydroxy Vitamin D.sub.3, biologically active Vitamin D.sub.3 derivatives which are capable of activating the intracellular Vitamin D.sub.3 receptor, all trans-retinoic acid, retinoic acid derivatives, retinol, retinol derivatives and glucocorticoid. The vaccine composition may further comprise an immune response augmenting agent which enhances T cell lymphokine production. Suitable immune response augmenting agents include dehydroepiandrosterone (DHEA) and DHEA-derivatives. Examples of DHEA derivatives include DHEA-sulfate (DHEA-S), 16-.alpha.-bromo-DHEA, 7-oxo-DHEA, 16-.alpha.-Br-DHEA-S and 7-oxo-DHEA-S. The invention also relates to a method for inducing an antigen-specific mucosal immune response in a vertebrate animal which comprises administering a vaccine which comprises an antigen and a lymphoid organ modifying agent with or without an immune response augmenting agent to a site which drains into a peripheral lymphoid compartment.
A method for inducing an antigen-specific mucosal immune response in a vertebrate animal, which comprises administering an effective amount of at least one lymphoid organ modifying agent to the vertebrate animal at a peripheral, non-mucosal site which drains into a peripheral lymphoid organ or compartment, and administering an effective amount of a specific antigen to the vertebrate animal at a peripheral, non-mucosal site which drains into said peripheral lymphoid organ or compartment, said lymphoid organ modifying agent selected from the group consisting of all trans-retinoic acid and 1,25(OH).sub.2 D.sub.3.
A vaccine composition comprising an effective amount of at least one lymphoid organ modifying agent and an effective amount of a specific antigen in a pharmaceutically acceptable carrier to induce an antigen-specific mucosal immune response, said lymphoid organ modifying agent is selected from the group consisting of all trans-retinoic acid and 1,25(OH).sub.2 D.sub.3.
Dependencies are inferred from the claim text.