Xenogeneic tissue implant in ear pinna
AssigneeSystemix, Inc.
InventorsBrian Ford, Hideto Kaneshima
Life of this patent
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Abstract
Immunocompromised hosts comprising xenogeneic fetal lymph node tissue implanted in the ear pinna are provided. The chimeric hosts are prepared by inserting the xenogeneic lymph node tissue into the ear pinna and closing the incision. The tissue is found to be rapidly vascularized and can be productively infected with HIV.
Claims10
A mouse host which is immunocompromised in lacking functional syngeneic B and T lymphocytes as a result of a genetic defect in immunoglobulin and T-cell receptor gene rearrangement, comprising vascularized viable xenogeneic non-malignant, non-transformed human fetal lymph node tissue in at least one ear pinna.
A mouse host which is immunocompromised in lacking functional syngeneic B and T lymphocytes as a result of a genetic defect in immunoglobulin and T-cell receptor gene rearrangement, comprising HIV infected, viable xenogeneic non-malignant, non-transformed human fetal lymph node tissue in at least one ear pinna.
A method for producing a chimeric mammal comprising a xenogeneic lymph node engrafted into an ear pinna, said method comprising:
- inserting through an incision human fetal lymph node tissue into the ear pinna of a mouse host which is immunocompromised in lacking functional syngeneic B and T lymphocytes as a result of a genetic defect in immunoglobulin and T-cell receptor gene rearrangement;
- and
- closing said incision and maintaining said mouse whereby said tissue becomes vascularized.
Dependencies are inferred from the claim text.