Leukotriene B.sub.4 antagonists
AssigneeG. D. Searle & Co.
InventorsSteven W. Djuric, Stella S. Yu
Life of this patent
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Abstract
This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof ##STR1## wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl; R.sup.1 is alkyl; R.sup.2 represents alkyl from 1 to 5 carbon atoms, aryl or aryl substituted with halogen or alkyl from 1 to 5 carbon atoms; R.sup.6 is alkyl; n is 1 to 5; p is 0 to 6; x is 0 or 2; and R.sup.4 and R.sup.5 are independently hydrogen or alkyl or together with N form a cycloalkylamine. The compounds of Formula I are leukotriene B.sub.4 antagonists and are useful as anti-inflammatory agents and in treating disease conditions mediated by LTB.sub.4.
Claims4
A compound of the formula:
- ##STR33## wherein R represents alkyl having 1 to 6 carbon atoms, alkenyl having 2 to 6 carbon atoms, alkynyl having 2 to 6 carbon atoms, or --(CH.sub.2).sub.m --R.sup.3 wherein R.sup.3 represents cycloalkyl of 3 to 5 carbons atoms and m is 1 or 2;
- R.sup.1 represents alkyl having 1 to 4 carbon atoms;
- R.sup.2 represents alkyl from 1 to 5 carbon atoms, phenyl or phenyl substituted with halogen or alkyl from 1 to 5 carbon atoms;
- R.sup.6 represents alkyl having 1 to 6 carbon atoms;
- n is an integer from 1 to 5;
- p is an integer from 0 to 6;
- x is 2;
- and
- R.sup.4 and R.sup.5 are independently hydrogen or alkyl having 1 to 4 carbon atoms, or R.sup.4 and R.sup.5 together with N form a cycloalkylamine having 4 to 5 carbon atoms;
- or a stereoisomer or pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.