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US 5,516,907 AGranted
Heterocyclic-substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
AssigneeG.D. Searle & Co.
InventorsJohn J. Talley, Donald J. Rogier, Jr.
Life of this patent
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Abstract
A class of pyrazolyl benzenesulfonamido compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## or a pharmaceutically-acceptable salt thereof.
Claims7
A compound of Formula I ##STR44## wherein R.sup.1 is sulfamyl;
- wherein R.sup.2 is haloalkyl;
- wherein R.sup.3 is selected from hydrido, and alkyl;
- and
- wherein R.sup.4 is heterocyclic;
- wherein R.sup.4 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfinyl, alkyl, alkylsulfonyl, cyano, carboxyl, alkoxycarbonyl, amido, N-monoalkylamido, N-monoarylamido, N,N-dialkylamido, N-alkyl-N-arylamido, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl, haloalkoxy, sulfamyl, N-alkylsulfamyl, amino, N-alkylamino, N,N-dialkylamino, heterocyclic, nitro and acylamino;
- provided R.sup.4 is not unsubstituted thienyl when R.sup.2 is trifluoromethyl;
- or a pharmaceutically-acceptable salt thereof.
4 more elements
A compound of Formula II ##STR45## wherein R.sup.2 is haloalkyl;
- wherein R.sup.3 is hydrido;
- and wherein R.sup.4 is heterocyclic;
- wherein R.sup.4 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfonyl, cyano, nitro, haloalkyl, alkyl, hydrido, alkoxy, haloalkoxy, sulfamyl, heterocyclic and amino;
- or a pharmaceutically-acceptable salt thereof.
1 more element
Dependencies are inferred from the claim text.