Antibiotic compounds and methods to treat gram-positive bacterial and mycoplasmal infections
AssigneeUniversity of Massachusetts Medical Center
InventorsNeal C. Brown, George Wright
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Abstract
A method of inhibiting replication of mycoplasmal and Gram-positive bacteria is described. Useful new compounds for in vivo and in vitro inhibition and therapy for infections utilize HPUra-like compounds are also provided. These include a number of novel 3-substituted uracil and isocytosine compounds, and 10-substituted guanine and adenine compounds.
Claims12
A 3-substituted uracil compound, or pharmaceutically acceptable salt thereof, having the formula ##STR14## wherein R.sub.1 is (CH.sub.2).sub.n OH, CH.sub.2 CHOHCH.sub.2 OH, CH.sub.2 CHOHCH.sub.3, (CH.sub.2).sub.m CO.sub.2 H, or (CH.sub.2).sub.n NH.sub.2, n is 2, 3, 4, or 5 and m is 1, 2, 3, or 4;
- and R.sub.2 is a 5-indanyl, ##STR15## where R.sub.3 and R.sub.4 are H, alkyl, or halo.
The compound of claim 18 wherein the 3-substituted uracil is 3-(Aminoethyl)-6-(5-indanylamino)uracil (AE-TMAU).
A 3-substituted isocytosine compound, or pharmaceutically acceptable salt thereof, having the formula ##STR16## wherein R.sub.1 is (CH.sub.2).sub.n OH, CH.sub.2 CHOHCH.sub.2 OH, CH.sub.2 CHOHCH.sub.3, (CH.sub.2).sub.m CO.sub.2 H, or (CH.sub.2).sub.n NH.sub.2, n is 2, 3, 4, or 5 and m is 1, 2, 3, or 4;
- and R.sub.2 is a 5-indanyl, ##STR17## where R.sub.3 and R.sub.4 are H, alkyl, or halo.
Dependencies are inferred from the claim text.