A.sub.2b -adenosine receptors

Abstract

Disclosed are cDNAs encoding A.sub.2b -adenosine receptors and the recombinant proteins expressed from such cDNAs. The recombinant receptor and receptor fragments and analogs are used in methods of screening candidate compounds for their ability to antagonize interaction between adenosine and an A.sub.2b -adenosine receptor; antagonists are used as therapeutics to reduce inflammatory gastrointestinal tract diseases or asthma. Antibodies specific for A.sub.2b -adenosine receptor (or receptor fragment or analog) and their use as a therapeutic and diagnostic are also disclosed.

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