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AssigneeCornell Research Foundation, Inc.
InventorsKeun-Ho Lee, Chih-Chang Chu, Jack H. Freed
Estimating the term…
Aminoxyl-containing radical is provided in polymers and copolymers by replacing a hydroxyl moiety in a carboxyl group at a chain end of a starting material biodegradable polymer or copolymer with imino or oxy linked to aminoxyl-containing radical to form an amide linkage or an oxycarbonyl linkage at the chain end of biocompatible polymers or copolymers to the aminoxyl-containing radical. Preferred starting material polymers and copolymers are prepared from the hydroxy alkyl carboxylic acid monomers glycolic acid and lactic acid. Preferred aminoxyl-containing radical is 2,2,6,6-tetramethylpiperidine-1-oxy. Product polymers are useful for aminoxyl-containing radical treatment of tumors, and to increase the efficiency of chemotherapy and ionizing radiation therapy of tumors and for the reconstruction of injured, diseased, or aged human blood vessels.
Biocompatible biodegradable polymer or copolymer containing a chain end having a carboxyl group modified to provide a moiety containing an aminoxyl-containing radical in place of the hydroxyl moiety of the carboxyl group except for spin labeled poly-L-glutamates, said polymer or copolymer being formed by replacing a hydroxyl moiety in a carboxyl group at a chain end of a starting material polymer or copolymer containing hydrolyzable ester or nitrogen-phosphorus linkage.
Polyalkylene terephthalate wherein the alkylene contains 2 to 4 carbon atoms, having a carboxyl group in its chain end modified to provide a moiety containing an aminoxyl-containing radical in place of the hydroxyl moiety of the carboxyl group.
Dependencies are inferred from the claim text.