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US 5,516,807 AGranted
Method for treating vascular proliferative disorders following balloon angioplasty
AssigneeWarner-Lambert Company
InventorsDonald Hupe, Joan A. Keiser
Life of this patent
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Abstract
Polyamines inhibit vascular smooth muscle proliferation and thus are useful in treating and preventing vascular proliferative disorders such as restenosis following balloon angioplasty.
Claims10
A method for treating or preventing restenosis following balloon angioplasty, restenosis following graft or shunt implantation, or restenosis following atherectomy comprising administering to a subject in need of treatment or prevention an effective amount of a polyamine of the formula ##STR4## wherein:
- R.sub.1 and R.sub.6 independently are hydrogen or C.sub.1 -C.sub.12 alkyl;
- R.sub.2, R.sub.3 , R.sub.4, and R.sub.5 independently are hydrogen or C.sub.1 -C.sub.12 alkyl;
- m and n are integers from 3 to 6;
- or a pharmaceutically acceptable salt thereof, provided at least one of R.sub.1, R.sub.2, R.sub.5, and R.sub.6 is C.sub.1 -C.sub.12 alkyl.
1 more element
Dependencies are inferred from the claim text.