Ornithine decarboxylase inhibiting cyclic aminooxy compounds
AssigneeCiba-Geigy Corporation
InventorsJorg Frei, Jaroslav Stanek
Life of this patent
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Abstract
Compounds of formula (I): H.sub.2 N--(CH.sub.2).sub.n --A--(CH.sub.2).sub.m --O--NH.sub.2 and salts thereof are described in which the radical A is C.sub.3 -C.sub.6 cycloalkylene; n is 0 or 1 and, independently thereof, m is 0 or 1; with the provisos that a) the distance between the aminooxy radical H.sub.2 N--O-- and the amino group --NH.sub.2 is at least 3 and not more than 4 carbon atoms and that b) the two radicals H.sub.2 N--(CH.sub.2).sub.n -- and --(CH.sub.2).sub.m --O--NH.sub.2 are not bonded to the same ring carbon of A. The compounds of formula (I) and their salts are ornithine decarboxylase inhibitors.
Claims25
A compound of the formula I
- H.sub.2 N--(CH.sub.2).sub.n --A--(CH.sub.2).sub.m --O--NH.sub.2(I)
- in which
- the radical A is C.sub.3 -C.sub.6 cycloalkylene;
- n is 0 or 1 and, independently thereof,
- m is 0 or 1;
- with the provisos that a) the distance between the aminooxy radical H.sub.2 N--O-- and the amino group --NH.sub.2 is at least 3 and not more than 4 carbon atoms and that b) the two radicals H.sub.2 N--(CH.sub.2).sub.n -- and --(CH.sub.2).sub.m --O--NH.sub.2 are not bonded to the same ring carbon atom of A, or a salt thereof.
A compound of the formula I,
- in which
- A is 1,2-cyclopropylene;
- 1,3-cyclobutylene;
- 1,3-cyclopentylene;
- or 1,3- or
- 1,4-cyclohexylene;
- m is 0 or 1 and
- n, independently of m, is 0 or 1;
- with the proviso that the distance between the aminooxy radical H.sub.2 N--O-- and the amino group --NH.sub.2 is at least 3 and not more than 4 carbon atoms;
- or a salt thereof.
Dependencies are inferred from the claim text.