Heteroatom substituted propanyl derivatives having 5-lipoxygenase inhibitory activity

A compound having the structure ##STR62## or a pharmaceutically acceptable salt thereof where L.sup.1 and L.sup.2 are independently a single bond or alkylene of one to three carbon atoms;

• L.sup.3 is ##STR63## where R.sup.15 is hydrogen or alkyl of one to four carbon atoms;
• Y is selected from oxygen and >S(O)n where n=0, 1, or 2;
• R.sup.1 is alkyl of one to four carbon atoms;
• W is oxygen or sulfur;
• R.sup.9 is alkyl of one to four carbon atoms;
• R.sup.10 is selected from the group consisting of
• (a) hydrogen,
• (b) alkyl of one to four carbon atoms,
• (c) haloalkyl of one to four carbon atoms,
• (d) cyanoalkyl of one to four carbon atoms,
• (e) unsubstituted phenyl,
• (f) phenyl substituted with a substituent selected from the group consisting of alkyl of one to four carbon atoms, alkoxy of one to four carbon atoms, haloalkyl of one to four carbon atoms, and halogen,
• (g) hydroxyalkyl of one to four carbon atoms,
• (h) aminoalkyl of one to four carbon atoms,
• (i) carboxyalkyl of one to four carbon atoms, and
• (j) (alkoxycarbonyl)alkyl where the alkyl and alkoxy portions are independently of one to four carbon atoms;
• R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are independently selected from the group consisting of
• hydrogen,
• alkyl of one to four carbon atoms,
• alkoxy of one to four carbon atoms,
• haloalkyl of one to four carbon atoms,
• halogen,
• cyano,
• amino,
• alkoxycarbonyl of one to four carbon atoms, and
• dialkylaminocarbonyl where the alkyl portions are each of one to four carbon atoms;
• and
• R.sup.16 and R.sup.17 are independently selected from the group consisting of
• hydrogen,
• alkyl of one to four carbon atoms,
• alkoxy of one to tour carbon atoms, and
• haloalkyl of one to four carbon atoms.