Synthesis and application of alkyl-substituted dibenzofurans as antitumorigenic agents
AssigneeTexas A&M University System Technology Licensing Office
InventorStephen H. Safe
Life of this patent
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Abstract
Provided is a method of inhibiting estrogen activity by administering a biologically active amount of a substituted dibenzofuran or substituted dibenzodioxin.
Claims16
A method of inhibiting estrogen activity comprising administering a biologically active amount of a compound of the formula:
- ##STR14## wherein R.sub.1, R.sub.3, R.sub.6 and R.sub.8 or R.sub.2, R.sub.4, R.sub.6 and R.sub.8 are individually and independently a hydrogen or a substituent selected from the group consisting of chlorine, fluorine and bromine, and a linear or branched alkyl group of one to four carbons,
- said compound having at least one alkyl substituent and at least two halogen substituents.
A method according to claim 5 wherein the alkyl substituent is methyl.
A method of inhibiting estrogen activity comprising administering a biologically active amount of a compound selected from the group consisting of
- 6-methyl-1,3,8-trichlorodibenzofuran,
- 8-methyl-1,3,6-trichlorodibenzofuran,
- 6-ethyl-1,3,8-trichlorodibenzofuran,
- 6-propyl-1,3,8-trichlorodibenzofuran,
- 6-methyl-2,3,8-trichlorodibenzofuran,
- 6-methyl-2,3,4,8-tetrachlorodibenzofuran,
- 8-methyl-1,3,7-trichlorodibenzofuran,
- 8-methyl-1,2,4,7-tetrachlorodibenzofuran,
- 8-methyl-2,3,7-trichlorodibenzofuran, and
- 8-methyl-2,3,7-tetrachlorodibenzofuran.
A method of inhibiting estrogen activity comprising administering a biologically active amount of a compound of the formula:
- ##STR15## wherein X, individually and independently, is a hydrogen or a substituent selected from the group consisting of bromine, chlorine, fluorine, and a linear or branched alkyl group of about one to about four carbons, with no more than one X being a hydrogen;
- wherein Y is a substituent selected from the group consisting of bromine, chlorine, fluorine, and a linear or branched alkyl group of about one to about four carbons;
- said compound having at least one alkyl substituent and at least two halogen substituents.
A method of inhibiting estrogen activity comprising administering a biologically active amount of a compound of the formula:
- ##STR16## wherein X, individually and independently, is a hydrogen or a substituent selected from the group consisting of bromine, chlorine, fluorine, and a linear or branched alkyl group of about one to about four carbons, with no more than one X being a hydrogen;
- wherein Y is a substituent selected from the group consisting of bromine, chlorine, fluorine, and a linear or branched alkyl group of about one to about four carbons;
- said compound having at least one alkyl substituent and at least two halogen substituents.
A method of treating estrogen-dependent tumors comprising administering a biologically active amount of a compound of the formula ##STR17## wherein X, individually and independently, is a hydrogen or a substituent selected from the group consisting of bromine, chlorine, fluorine, and a linear or branched alkyl group of about one to about four carbons, with no more than one X being a hydrogen;
- wherein Y is a substituent selected from the group consisting of bromine, chlorine, fluorine, and a linear or branched alkyl group of about one to about four carbons;
- and
- said compound having at least one alkyl substituent and at least two halogen substituents.
A method of treating estrogen-dependent tumors comprising administering a biologically active amount of a compound of the formula ##STR18## wherein X, individually and independently, is a hydrogen or a substituent selected from the group consisting of bromine, chlorine, fluorine, and a linear or branched alkyl group of about one to about four carbons, with no more than one X being a hydrogen;
- wherein Y is a substituent selected from the group consisting of bromine, chlorine, fluorine, and a linear or branched alkyl group of about one to about four carbons;
- and
- said compound having at least one alkyl substituent and at least two halogen substituents.
Dependencies are inferred from the claim text.