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US 5,516,779 AGranted
17.beta.-substituted-6-azasteroid derivatives useful as 5.alpha.-reductase inhibitors
AssigneeMerck & Co., Inc.
InventorsDerek Von Langen, Donald W. Graham, Richard L. Tolman
Life of this patent
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Abstract
Compounds of the formula ##STR1## are inhibitors of 5 .alpha.-reductase and are useful alone or in combination with other active agents for the treatment of hyperandrogenic disorders such as acne vulgaris, seborrhea, female hirsutism, male pattern baldness, and benign prostatic hyperplasia.
Claims9
A compound of the formula I ##STR11## or a pharmaceutically acceptable salt thereof, wherein:
- R 1 is selected from -H,-CH.sub.3 and-CH.sub.2 CH.sub.3 ;
- R.sup.2 is selected from:
- (1) -H,
- (2) -C.sub.1-12 alkyl,
- (3) -C.sub.1-12 alkyl-phenyl,
- (4) -O-C.sub.1-12 alkyl or-S(O).sub.n -C.sub.1-12 alkyl,
- (5) -O-phenyl or-S(O).sub.n -phenyl,
- (6) -C.sub.1-6 alkyl-X-C.sub.1-12 alkyl, and
- (7) -NR.sup.3 R.sup.4, wherein R.sup.3 and R.sup.4 are each independently selected from -H, C.sub.1-12 alkyl, and phenyl;
- X is selected from the group consisting of O, NH and S(O).sub.n ;
- and
- n is zero, 1 or 2.
9 more elements
Dependencies are inferred from the claim text.