Method for improving tissue antioxidant status
AssigneeChinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
InventorsFerenc Ender, Jozsef Furesz, Laszlo Rosivall, Katalin Schweitzer
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Abstract
The invention relates to a method of using 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione (generic name:pentoxifylline) and/or 1-(3',4'-diethoxybenzyl)-6,7-diethoxy-3,4 -dihydroisoquinolinium theophylline-7-acetate (Depogen) or monohydrate thereof to improve mammalian tissue antioxidant status. This status plays an important role in complications, occurring as a consequence of pathologically developed or artificially established anastomoses, particularly anastomosis of oesophagus and colon since these organs possess a very weak antioxidant protective system.
Claims4
A method of accelerating a healing process of an anastomosis in a mammalian subject with said anastomosis, which comprises the step of administering to said mammalian subject a therapeutically effective amount of a compound selected from the group consisting of:
- 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione;
- 1-(3',4'-diethoxybenzyl)-6,7-diethoxy-3,4-dihydro-isoquinolinium-theophylli ne-7-acetate or its monohydrate;
- and
- mixtures thereof.
A pharmaceutical composition for accelerating a healing process of an anastomosis which comprises a therapeutically effective amount of a mixture of:
- 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione;
- and
- 1-(3',4'-diethoxybenzyl)-6,7-diethoxy-3,4-dihydro-isoquinolinium theophylline-7-acetate or its monohydrate;
- in combination with a pharmaceutically acceptable inert carrier.
A method of treatment for improving tissue antioxidant status of a mammalian subject in need of said treatment, which comprises the step of administering to said mammalian subject a therapeutically effective amount of
- 1-(3',4'-diethoxybenzyl)-6,7-diethoxy-3,4-dihydro-isoquinolinium theophylline-7-acetate or its monohydrate;
- or a therapeutically effective amount of a mixture of
- 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione;
- and
- 1-(3',4'-diethoxybenzyl)-6,7-diethoxy-3,4-dihydroisoquinolinium theophylline-7-acetate or its monohydrate.
Dependencies are inferred from the claim text.