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US 5,516,762 AGranted
Method of treating endotoxin effects with 2-haloadenosine nucleotide analogs
AssigneeWisconsin Alumni Research Foundation
InventorsPaul J. Bertics, Richard A. Proctor
Life of this patent
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Abstract
A method of treating a mammal exposed to endotoxin in order to reduce the detrimental effects of said endotoxin, comprising administering to said mammal a therapeutically effective amount of a 2-halo-adenosine nucleotide analog. 2-Cloro-ATP is the preferred species of the 2-halo-adenosine nucleotide. The nucleotide used in this treatment inhibits lipo-polysaccharide-induced GTPase activity.
Claims3
A method of reducing the damage caused by entotoxin in a mammal comprising administering to said mammal a therapeutic amount of a compound of the following formula:
- ##STR2## wherein X.sub.1 is --O--, --NH--, or --CH.sub.2 --;
- X.sub.2 is --OH, --NH.sub.2, or --CH.sub.3 ;
- X.sub.3 is --OH;
- R.sub.1 is a halogen;
- R.sub.2 is is --NH.sub.2, --HN(CH.sub.3), or--NH(lower alkyl).sub.2 ;
- and
- n is 0 or 1.
4 more elements
Dependencies are inferred from the claim text.