Pyridinoline crosslinks as markers of periodontal and peri-implant disease activity
AssigneesInstitute of Molecular Biology, Inc., President and Fellows of Harvard College
InventorsWilliam V. Giannobile, Ray C. Williams, Samuel E. Lynch
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Abstract
A method of diagnosing severity of periodontal disease or peri-implant disease in a human patient, involving a) obtaining a sample of tissue or gingival crevicular or other fluid from the mouth of said patient, or a blood or urine sample from the patient, and b) measuring a pyridinoline crosslinked compound in the sample as a measure of severity of disease.
Claims11
A method of determining the presence or progression of periodontal disease or peri-implant disease in a mammal, said method comprising
- a) obtaining a sample of gingival crevicular fluid from the mouth of said mammal, and
- b) measuring a pyridinoline crosslinked compound in said sample as a measure of disease progression or risk.
A method of determining the presence or progression of periodontal or peri-implant disease in a mammal, said method comprising
- a) obtaining a sample of blood from the mammal, and
- b) measuring a pyridinoline crosslinked compound in said sample as a measure of disease progression or presence.
Dependencies are inferred from the claim text.