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US 5,516,690 AGranted
Ketoprofen resolution by ester hydrolysis using Trichosporon laibacchii
AssigneeLaborabotios Menarini, S.A.
InventorsChriatopher T. Evans, Richard A. Wisdom, Peter J. Stabler, Germano Carganico
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Abstract
Arylalkanoic acids are produced by biotransformation using suitable microorganisms and, in particular, (S)-ketoprofen in greater than 95% purity from racemic ketoprofen ethyl ester.
Claims7
A process of preparing an enantiomer of 2-(3-benzoylphenyl)propionic acid from a mixture of (R) and (S) 2-(3-benzoylphenyl)propionic acid alkyl esters comprising:
- combining a mixture of (R) and (S) 2-(3-benzoylphenyl)propionic acid alkyl esters with Trichosporon laibacchii;
- hydrolyzing the ester of predominantly an enantiomer of said mixture;
- and
- recovering the enantiomer of 2-(3 -benzoylphenyl)propionic acid prepared.
1 more element
Dependencies are inferred from the claim text.