Human D4 dopamine receptor and its uses
AssigneeState of Oregon, Acting by and Through the Oregon State Board of Higher Education on Behalf of the Oregon Health Sciences University, a non-profit organization
InventorsDavid K. Grandy, James R. Bunzow, Olivier Civelli, Hubert H.-M. Van Tol
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Abstract
The present invention is directed toward the isolation, characterization and pharmacological use of the human D4 dopamine receptor. The nucleotide sequence of the gene corresponding to this receptor and alleleic variants thereof are provided by the invention. The invention particularly provides recombinant eukaryotic expression constructs capable of expressing the human D4 dopamine receptor at useful levels in cultures of transformed eukaryotic cells. The invention provides cultures of transformed eukaryotic cells which synthesize such useful amounts of human D4 dopamine receptor protein, and methods for characterizing novel psychotropic compounds using such cultures.
Claims10
A recombinant expression construct capable of expressing a human dopamine receptor gene in a mammalian host cell, the construct comprising a vaccinia virus vector operably linked to a nucleic acid encoding a human D4 dopamine receptor.
A nucleic acid comprising a vaccinia virus-derived vector that is the vector pZVneo covalently linked to a nucleic acid encoding a human D4 dopamine receptor.
Dependencies are inferred from the claim text.