Truncated thrombomodulin, recombinant production thereof, and therapeutic agent
AssigneeMochida Pharmaceutical Co., Ltd.
InventorsAtsushi Nii, Hideaki Morishita, Akio Uemura, Ei Mochida
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Abstract
This invention relates to a novel polypeptide which is obtained by means of genetic recombination DNA techniques and has thrombin binding ability, anticoagulant activity and thrombolytic activity. The polypeptide of the present invention can be produced in a large quantity and efficiently by means of genetic recombination techniques. Since the polypeptide of the present invention exhibits anticoagulant activity and thrombolytic activity without generating side effects such as bleeding tendency, it can be applied effectively to the prevention and treatment of hypercoagulability-related diseases.
Claims13
A recombinant polypeptide consisting of an amino acid sequence corresponding to SEQ ID NO:1 or SEQ ID NO:2 with (a) at least one amino acid and no more than 21 amino acids deleted from the N-terminus of SEQ ID NO:1 or SEQ ID NO:2, (b) at least one and no more than 11 amino acids deleted from the C-terminus of SEQ ID NO:1 or SEQ ID NO:2, or both (a) and (b);
- or a functionally equivalent homologue.
The polypeptide according to 1, wherein said amino acid sequence has at least one N-linked or O-linked sugar chain.
Dependencies are inferred from the claim text.