Synthetic peptides
AssigneeDuke University
InventorsThomas J. Palker, Barton F. Haynes
Life of this patent
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Abstract
The present invention relates to immunogenic preparations of peptides comprising amino acid sequences corresponding to antigenic determinants of the envelope glycoprotein of HTLV-I or HTLV-II covalently coupled, directly or through a spacer molecule, to carrier molecules suitable for vaccination of mammals. The invention also relates to the use of such peptides in diagnostic assays.
Claims26
A peptide having an amino acid sequence selected from the group consisting of (C) PHWTKKPNRNGGGYYSASYSDP (SEQ ID NO:3);
- (C) LNTEPSQLPPTAPP (Y) (SEQ ID NO:4);
- and
- (C) LLPHSNLDHILEPSIPWKSK (Y) (SEQ ID NO:6).
A peptide having an amino acid sequence selected from the group consisting of SSYHSSPCSPTQPVC (SEQ ID NO:15);
- CTWNLDLNSLTTDQRLHPPC (SEQ ID NO:16);
- HWIKKPNRQGLGYYSPSYNDPC (SEQ ID NO:17);
- (C)SSPSWKFHSDVNFTQE (SEQ ID NO:18);
- (C) SEPTQPPPTSPPLVHDSDLEH (SEQ ID NO:19);
- and (C)SLAPVPPPATRRRR (SEQ ID N0:20).
A peptide having the amino acid sequence PHWIKKPNRQGLGYYS (C) (SEQ ID NO:
- 14).
A peptide having the amino acid sequence WTKKPNRNGGG (amino acids 4-14 of SEQ ID NO:3).
A chimeric peptide having the amino acid sequence LPPTAPPLLPHSNLDHILEPSIPWKSKWTKKPNRNGGG (SEQ ID NO:25).
A peptide having the sequence PHWIKKPNRQGLGYYS (amino acids 1-16 of SEQ ID NO:14).
A subsequence of a peptide having the amino acid sequence (C)PHWTKKPNRNGGGYYSASYSDP (SEQ ID NO:3) that includes the amino acid sequence WTKKPNRNGGG (amino acids 4-14 of SEQ ID NO:3).
A peptide having the amino acid sequence
- (C)PHWTKKPNRNGGGYYSASYSDP (SEQ ID NO:3).
A peptide having the amino acid sequence
- (C)LNTEPSQLPPTAPP(Y) (SEQ ID NO:4).
A peptide having the amino acid sequence LPPTAPPLLPHSNLDHILEPSIPWKSKWTKKPNRNGGG (SEQ ID NO:25), or portion thereof that includes at least the amino acids WTKKPNRNGGG (amino acids 28-38 of SEQ ID NO:25).
Dependencies are inferred from the claim text.