Back to results
US 5,516,530 AGranted
Porous shaped delivery devices and method of producing thereof
AssigneePfizer Inc.
InventorsJulian B. Lo, Gary G. Mackay, Michael J. Puz
Life of this patent
Estimating the term…
Abstract
High strength, high porosity delivery devices have a shaped surface and disintegrate quickly in an aqueous medium. The devices can be prepared by disposing a formulation in a die to form a frozen predevice. A second die is contacted with the frozen formulation surface at a pressure and temperature for a time sufficient to locally momentarily liquify and shape the device surface. The shaping is followed by lyophilization.
Claims15
A porous, compressed shaped delivery device comprising:
- a) about 5% to about 95% water soluble polymer;
- and
- b) about 0.01 mg to about 1000 mg active agent;
- wherein said device has a porosity of at least about 85%, said porosity void of active agent and said device has a predetermined molded shape over the entire device surface.
1 more element
A method for making a porous shaped delivery device comprising:
- a). disposing a formulation into a first die, said formulation comprising about 0.01 mg to about 1000 mg beneficial agent and about 1% to about 10% water soluble polymer;
- b). freezing said formulation to form a frozen predevice;
- c). contacting a second die with the exposed frozen predevice surface at a pressure, temperature and time sufficient to locally liquify, shape and refreeze said surface;
- and
- d). lyophilizing said frozen predevice to form said porous, shaped delivery device, said device having aporosity of about 85% to about 98%, said porosity void of active agent.
2 more elements
Dependencies are inferred from the claim text.