Succinimide derivatives and process for preparing the same
AssigneeTanabe Seiyaku Co., Ltd.
InventorsTameo Iwasaki, Takashi Nishitani, Akio Ohtani, Masanori Inamasu
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Abstract
Novel succinimide derivatives of formula I!: ##STR1## wherein Ring A is tri-lower alkoxyphenyl, R.sup.1 and R.sup.2 combine each other to form a group of the formula: >N--R.sup.3 or one of R.sup.1 and R.sup.2 is lower alkoxy, and the other is group of the formula: --NHR.sup.3, in which R.sup.3 is hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted amino, hydroxy or pyridylcarbonyl, or salts thereof, these compounds have excellent antithrombotic activity and are useful as antithrombotic drug, or synthetic intermediate for preparing other antithrombotic drug.
Claims22
A succinimide derivative of formula (I):
- ##STR44## wherein, the configuration of the double bond attached to the carbon atom at the 3-position of the succinimide formula (I) derivative is E or Z;
- the configuration of the double bond attached to the carbon atom at the 4-position thereof is E;
- Ring A is a phenyl group substituted by three C.sub.1-6 alkoxy groups;
- and R.sup.3 is selected from the group consisting of a hydrogen atom, a C.sub.1-6 alkyl group, a C.sub.1-6 alkyl group substituted by one to three substituents selected from the group consisting of a hydroxy group, a C.sub.1-6 alkoxy group, a carboxyl group, a (C.sub.1-6 alkoxy) carbonyl group, a phenyl-(C.sub.1-6 alkoxy) carbonyl group, a di-(C.sub.1-6 alkyl)amino group, a phenyl group, a 2-pyridyl group, a 4-pyridyl group and a morpholino group, a C.sub.1-6 alkoxy group, a C.sub.1-6 alkoxy group substituted by a substituent selected from the group consisting of a C.sub.1-6 alkoxy group and a phenyl group, an amino group, a di-(C.sub.1-6 alkyl)amino group, a 3-pyridylcarbonyl group, and a 4-pyridylcarbonyl group, and a pharmaceutically acceptable salt thereof.
3- (E)-Benzylidene!4- (E)-3,4,5-trimethoxybenzylidene!-2,5-pyrrolidinedi one or a pharmaceutically acceptable salt thereof.
(3E,4E)-1-Methoxy-3-benzylidene-4-(3,4,5-trimet hoxybenzylidene)-2,5-pyrrolidinedione or a pharmaceutically acceptable salt thereof.
A succinimide derivative of formula (I):
- ##STR45## wherein the configuration of the double bonds attached to the carbon atoms at the 3- and 4-positions of the succinimide formula (I) derivative is E;
- Ring A is a phenyl group substituted by three C.sub.1-6 alkoxy groups;
- and R.sup.3 is selected from the group consisting of a C.sub.1-6 alkyl group, a C.sub.1-6 alkyl group substituted by one to three substituents selected from the group consisting of a hydroxy group, a C.sub.1-6 alkoxy group, a carboxyl group, a (C.sub.1-6 alkoxy) carbonyl group, a phenyl(C.sub.1-6 alkoxy) carbonyl group, a di-(C.sub.1-6 alkyl)amino group, a phenyl group, a 2-pyridyl group, a 4-pyridyl group and a morpholino group, a C.sub.1-6 alkoxy group, a C.sub.1-6 alkoxy group substituted by a substituent selected from the group consisting of a C.sub.1-6 alkoxy group and a phenyl group, an amino group, a di-(C.sub.1-6 alkyl)amino group, a 3-pyridylcarbonyl group, and a 4-pyridylcarbonyl group, and a pharmaceutically acceptable salt thereof.
A succinimide derivative of formula (I):
- ##STR46## wherein the configuration of the double bond attached to the carbon atom at the 3-position of the succinimide formula (I) derivative is E or Z;
- the configuration of the double bond attached to the carbon atom at the 4-position of the succinimide formula (I) derivative is E;
- Ring A is a phenyl group substituted by three C.sub.1-6 alkoxy groups;
- and R.sup.3 is a hydrogen atom and a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.