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US 5,514,814 AGranted
Pyrrolinone-based compounds
AssigneeThe Trustees of the University of Pennsylvania
InventorsRalph F. Hirschmann, Amos B. Smith, III, Paul Sprengeler, David Jones
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Abstract
This invention relates to monomeric and polymeric pyrrolinone-based compounds, to the use of pyrrolinone-based compounds in place of amino acids in naturally-occurring or synthetic peptides, and to methods for preparing such compounds.
Claims9
A compound having structure:
- ##STR18## wherein:
- R.sub.B1 is OR.sub.D, NR.sub.D R.sub.D, a N-terminal amino acid, a N-terminal peptide, a group that improves the pharmacokinetic properties of the compound, or a group that improves the pharmacodynamic properties of the compound;
- each R.sub.C is, independently, an amino acid side chain;
- R.sub.D is H, an amine protecting group, or alkyl having 1 to about 7 carbon atoms;
- n is 0-5;
- m is 0-5;
- x is 1-5;
- and
- y is 0-200.
6 more elements
Dependencies are inferred from the claim text.