Process for synthesizing 4-halo-5-(hydroxymethyl) imidazole compounds
AssigneeShikoku Chemicals Corporation
InventorsTakayuki Murai, Tokuichi Saeki, Suzuko Satou, Shozo Miura, Tomoko Takashige, Naoki Kano
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Abstract
A process for preparing, on an industrial scale, 4-halo-5-(hydroxymethyl) imidazole compounds that are useful as intermediates for medicines. A 4-chloro-5-(hydroxymethyl) imidazole compound, a 4-bromo-5-(hydroxymethyl) imidazole compound or a like compound is synthesized by reacting a 4,5-bis(hydroxymethyl) imidazole compound with a halogenating agent such as an N-chlorosuccinimide, an N-bromosuccinimide, a chlorinated isocyanuric acid compound or the like compound.
Claims4
A process for synthesizing a 4-chloro-5-(hydroxymethyl) imidazole compound represented by the following formula ##STR8## wherein R is a hydrogen atom, an alkyl group, an aryl group or an aralkyl group,
- which comprises reacting a 4,5-bis(hydroxymethyl) imidazole compound with a chlorinating agent.
Dependencies are inferred from the claim text.