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US 5,514,804 AGranted
Diastereomer salt of optically active quinolinemevalonic acid
AssigneeNissan Chemical Industries, Ltd.
InventorsYoshio Ohara, Mikio Suzuki, Yoshinobu Yanagawa, Hiroshi Iwasaki, Nobuhide Miyachi
Life of this patent
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Abstract
A diastereomer salt of optically active quinolinemevalonic acid of the formula ((-)I.multidot.(+)II): ##STR1##
Claims8
A process for producing optically active quinolinemevalonolactone of the formula (III):
- ##STR10## which comprises dehydrating an optically active quinolinemevalonic acid of the formula ((-)I):
- ##STR11##
A process for producing an optically active quinolinemevalonic acid salt of the formula (IV):
- ##STR12## which comprises reacting an optically active quinolinemevalonic acid of the formula ((-)I):
- ##STR13## with a base, wherein R.sup.8 is Na, Ka, 1/2 Ca or HNR.sup.2 R.sup.3 R.sup.4, wherein each of R.sup.2, R.sup.3 and R.sup.4 is hydrogen, C.sub.1 -C.sub.3 lower alkyl or 2-hydroxyethyl;
- or when R.sup.2 is hydrogen or methyl, R.sup.3 and R.sup.4 together form --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.5 --, --(CH.sub.2).sub.2 --O--(CH.sub.2).sub.2 -- or --(CH.sub.2).sub.2 --NH--(CH.sub.2).sub.2 --.
Dependencies are inferred from the claim text.