Back to results
US 5,514,802 AGranted
Intermediates for preparing HIV protease inhibitors
AssigneeEli Lilly and Company
InventorsJames E. Fritz, Marlys Hammond, Stephen W. Kaldor
Life of this patent
Estimating the term…
Abstract
The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating and/or preventing HIV infection and/or AIDS.
Claims1
A compound of formula Ia ##STR18## wherein:
- R.sup.1 is aryl or C.sub.5 -C.sub.7 cycloalkyl;
- X is a group having the structure ##STR19## Y is aryl or unsaturated heterocycle;
- R.sup.1 is heterocycle;
- R.sup.3a is a group having the structure:
- ##STR20## R.sup.3b is a group having the structure:
- ##STR21## where p is 4 or 5;
- l is 3, 4 or 5;
- R.sup.4 at each occurrence is independently hydrogen, C.sub.1 -C.sub.6 alkyl or hydroxy(C.sub.1 -C.sub.4)alkyl;
- R.sup.5 and R.sup.6 are independently selected from hydrogen, hydroxy, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, amino, C.sub.1 -C.sub.4 alkylamino, hydroxy(C.sub.1 -C.sub.4)alkyl, carboxy, C.sub.1 -C.sub.4 alkoxycarbonyl, carbamoyl, N-(C.sub.1 -C.sub.4)alkylcarbamoyl, aryl, heterocycle or unsaturated heterocycle;
- or a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.