Use of azoles as virucidal agents in solutions of biologically active proteins
AssigneeBayer Aktiengesellschaft
InventorsMilton B. Dobkin, Paul Ng, George B. Dove
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Abstract
Soluble azoles in aqueous solutions can be used as virucidal agents for biologically active protein preparations.
Claims6
A method of inactivating both enveloped and non-enveloped viruses in an aqueous solution of therapeutic, biologically active proteins selected from the group consisting of coagulation factors and antibodies comprising the step of contacting the solution with an azole selecting from the group consisting of imidazole, histidine, 2-imidazolidinone, and 1H-imidazole-4-ethanamine under conditions sufficient to result in a reduction of at least 2 logs virus titer and recovery of greater than 50% of biological activity of the proteins.
Dependencies are inferred from the claim text.