Depsipeptide derivatives, production thereof and use thereof
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsHitoshi Nishiyama, Masaru Ohgaki, Ryo Yamanishi, Toshihiko Hara
Life of this patent
Estimating the term…
Abstract
wherein A is benzyl group which has suitable substituent(s) or phenyl group which may have suitable substituent(s), A.sup.a is benzyl group which may have suitable substituent(s) or phenyl group which may have suitable substituent(s), B and D are each lower alkyl, C is hydrogen or lower alkyl, and a pharmaceutically acceptable salt thereof. The compound or a salt thereof of the present invention has excellent parasiticidal activities as an anthelmintic agent for animals and human bodies.
Claims12
A compound of the general formula (I):
- ##STR46## wherein A is a substituted benzyl group or a phenyl group which may have substituent(s),
- A.sup.a is a benzyl group which may have substituent(s) or a phenyl group which may have substituent(s),
- B and D are each lower alkyl, and
- C is hydrogen or lower alkyl,
- or a pharmaceutically acceptable salt thereof.
A compound of the formula:
- ##STR47##
A compound of the formula:
- ##STR48##
A process for preparation of a compound of the general formula:
- ##STR49## or a salt thereof, which comprises subjecting a compound of the general formula:
- ##STR50## or a salt thereof, to a monoalkylation reaction followed by an intramolecular reaction,
- wherein B and D are each lower alkyl,
- C is hydrogen or lower alkyl,
- A.sup.3 is a benzyl group substituted by amino, or a benzyl group substituted by amino and lower alkoxy, and
- A.sup.5 is a benzyl group substituted by cyclic amino, or a benzyl group substituted by cyclic amino and lower alkoxy.
A process for preparation of a compound of the general formula:
- ##STR51## or a salt thereof, which comprises subjecting a compound of the general formula:
- ##STR52## or a salt thereof, to an alkylation reaction, wherein B and D are each lower alkyl,
- C is hydrogen or lower alkyl,
- A.sup.3 is a benzyl group substituted by amino, or a benzyl group substituted by amino and lower alkoxy, and
- A.sup.4 is a benzyl group substituted by mono- or di-lower alkylamino, or a benzyl group substituted by mono- or di-lower alkylamino and lower alkoxy.
Dependencies are inferred from the claim text.