Benzothiophene compounds useful for inhibiting lipoxygenase
AssigneeEli Lilly and Company
InventorsDonald G. Carlson, George J. Cullinan, Kennan J. Fahey, William T. Jackson, Neal W. Roehm, Stephen M. Spaethe
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Abstract
A method of inhibiting 5-lipoxygenase comprising administering to a mammal in need thereof an effective amount of a compound having the formula ##STR1## wherein R.sub.1 and R.sub.2 are independently hydrogen or C.sub.1 -C.sub.6 alkyl; R.sub.3 is hydrogen, or a group of the formula ##STR2## wherein R.sub.4 phenyl, substituted phenyl, naphthyl or substituted naphthyl, with the proviso that when R.sub.1 and R.sub.2 are both C.sub.1 -C.sub.6 alkyl, R.sub.3 is not hydrogen; and pharmaceutically acceptable salts thereof.
Claims5
A method of inhibiting 5-lipoxygenase comprising administering to a mammal in need thereof an effective amount of a compound of formula I ##STR7## wherein R.sub.1 and R.sub.2 are independently hydrogen or C.sub.1 -C.sub.6 alkyl;
- R.sub.3 is hydrogen, or a group of the formula ##STR8## wherein R.sub.4 is phenyl, substituted phenyl, naphthyl or substituted naphthyl with the proviso that when R.sub.1 and R.sub.2 are both C.sub.1 -C.sub.6 alkyl, R.sub.3 is not hydrogen;
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.