Arylamidoalkyl-N-hydroxyurea compounds having lipoxygenase inhibitory activity

A compound having the structure ##STR18## or a pharmaceutically acceptable salt thereof wherein R.sup.1 is NR.sup.2 R.sup.3 where R.sup.2 and R.sup.3 are independently selected from hydrogen and alkyl of from one to six carbon atoms;

• A is ##STR19## wherein R.sup.4 is selected from (a) phenoxy, optionally substituted with one, two, or three halogen atoms, alkyl of from one to six carbon atoms, haloalkyl of from one to six carbon atoms, phenylalkoxy in which the alkoxy portion is of from one to six carbon atoms, and
• (b) thiophenoxy, optionally substituted with one, two, or three halogen atoms, alkyl of from one to six carbon atoms, haloalkyl of from one to six carbon atoms;
• Y is a valence bond or is selected from
• alkylene of from one to six carbon atoms,
• alkenylene of from two to six carbon atoms, and
• oxyalkylene of from one to six carbon atoms;
• Z is oxygen or sulfur;
• B is ##STR20## wherein R.sup.9 is selected from hydrogen,
• alkyl of from one to six carbon atoms, and
• D is straight or branched chain alkylene of from one to six carbon atoms;
• and
• M is hydrogen or a pharmaceutically acceptable cation.