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US 5,514,701 AGranted
Pyrrolidine derivatives
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsHiroyuki Setoi, Akihiko Sawada, Hirokazu Tanaka, Masashi Hashimoto
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Abstract
This invention relates to pyrrolidine derivatives and pharmaceutically acceptable salts, their pharmaceutical compositions, and methods of use as thromboxane A.sub.2 antagonists and/or thromboxane A.sub.2 synthetase inhibitors in the treatment of thrombotic diseases, asthma or nephritis, e.g. of the formula: ##STR1## wherein R.sup.1 is thienyl(lower)alkyl, furyl(lower)alkyl or pyrrolyl(lower)alkyl.
Claims5
A compound of the formula:
- ##STR5## wherein R.sup.1 is thienyl(lower)alkyl, furyl(lower)alkyl or pyrrolyl(lower)alkyl,
- R.sup.2 is hydrogen or an acyl group, and
- R.sup.3 is carboxyl(lower)alkyl,
- protected carboxyl(lower)alkyl,
- carboxyaryl or protected carboxyaryl, and
- a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.