Antifungal vaginal cream composition

A method for making a long-lasting viscous antifungal vaginal cream composition comprising the following steps:

• (a) mixing an oil phase comprising an aliphatic alcohol, an ester and a surfactant;
• (b) separately mixing an aqueous phase comprising water and a humectant;
• (c) separately, mixing surfactant, water and an antifungal agent and creating a slurry;
• (d) separately mixing an alkaline buffer compound and water;
• (e) adding said aqueous phase to said oil phase, mixing and cooling the resulting mixture;
• (f) after step (e), adding said slurry to the resulting mixture;
• and
• (g) adding the alkaline buffer compound and water mixture to adjust the pH of the resulting mixture.

A long-lasting viscous antifungal vaginal cream composition comprising about 0.4 to 10.0% of an imidazole antifungal agent;

• about 1.0% to 5.0% of a fatty acid ester;
• about 1.0% to 25.0% of aliphatic alcohols;
• about 2.0% to 5.0% of a surfactant;
• about 0.02% to 0.20% of an antioxidant;
• a sufficient amount of inorganic base to adjust the pH range to a value of about 3.0 to 7.0 and water, said surfactant having an HLB which is close to the HLB value of the oil phase of the composition.