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US 5,514,697 AGranted
Immunosuppressive agents
AssigneeThe University of Sheffield
InventorsDavid N. Jones, John L. Maddocks
Life of this patent
Estimating the term…
Abstract
A compound with immunosuppressive properties having formula (I), in which R.sup.1 represents a heterocyclic ring system, a combined heterocyclic ring system and homocyclic ring system, or an ethoxycarbonylmethyl group. R.sup.2 and R.sup.3 represent hydrogen or lower alkyl groups.
Claims4
A method of suppressing the immune system of a human comprising administering to a person requiring same an effective amount of a compound of the following formula:
- ##STR30## in which R.sup.1 is ##STR31## in which R.sup.10 is hydrogen or an alkoxy group;
- and
- R.sup.7 is hydrogen, alkyl, nitro, halide or an alkoxy group;
- and
- R.sup.8 is hydrogen, halide or an alkoxy group;
- and
- R.sup.9 is hydrogen or an alkoxy group, and
- R.sup.2 is a hydrogen, alkyl or aryl;
- and
- R.sup.3 is a hydrogen, alkyl, aryl or nitroaryl.
7 more elements
A compound comprising the following formula:
- ##STR34## wherein the molecular groups R.sup.1, R.sup.2, and R.sup.3 are defined as one of the following:
- R.sup.1 is defined as the following:
- ##STR35## in which R.sup.2 is methyl;
- and
- R.sup.3 is hydrogen;
- and
- R.sup.7, R.sup.8, R.sup.9, R.sup.10 are one of the following combinations;
- R.sup.9 and R.sup.10 are both hydrogen, and R.sup.7 and R.sup.8 are both methoxy groups;
- or
- R.sup.8, R.sup.9, R.sup.10 are all hydrogen and R.sup.7 is methyl;
- or
- R.sup.8, R.sup.9, R.sup.10 are all hydrogen and R.sup.7 is a nitro group;
- or
- R.sup.9 and R.sup.10 are both hydrogen, R.sup.7 is fluorine, and R.sup.8 is chlorine;
- or
- R.sup.7 and R.sup.8 are both hydrogen and R.sup.9 and R.sup.10 are both methoxy groups.
13 more elements
Dependencies are inferred from the claim text.