Carbocyclic adenosine analogs useful as immunosuppressants
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsDavid R. Borcherding, Carl K. Edwards, III, Ronald E. Esser
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Abstract
This invention relates to carbocyclic adenosine compounds of the formula (1) ##STR1## wherein the hydroxy substituent on the cyclopentanyl ring is in the CIS configuration relative to the bicyclic substituent, Y.sub.3, Y.sub.7, Y.sub.8 and Y.sub.9 are each independently nitrogen or a CH group, Q is NH.sub.2, halogen or hydrogen, and Z is hydrogen, halogen, or NH.sub.2 ; or a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants.
Claims17
A compound of the formula ##STR7## wherein the hydroxy substituent on the cyclopentanyl ring is in the CIS configuration relative to the bicyclic substituent,
- Y.sub.3 is CH, Y.sub.7, Y.sub.8 and Y.sub.9 are each independently nitrogen or a CH group,
- Q is NH.sub.2, halogen or hydrogen, and
- Z is hydrogen, halogen, or NH.sub.2 ;
- or a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.