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US 5,514,684 AGranted
Aconitine compounds and analgesic/anti-inflammatory agent containing the same
AssigneeSanwa Shoyaku Kabushiki Kaisha
InventorsMitsuo Murayama, Takao Mori
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Abstract
Novel aconitine compounds of the formula ##STR1## wherein the symbols are as defined in the description, as well as analgesic/anti-inflammatory agent containing them or salts thereof as active ingredient.
Claims2
An aconitine compound of the formula (I):
- ##STR5## wherein R.sub.1 is
- (i) acyclic or cyclic, saturated or unsaturated alkyl having 1-8 carbon atoms,
- (ii) oxygen- or nitrogen-containing 5- or 6-membered heterocyclic group,
- (iii) acyl derived from an aromatic or aromatic-aliphatic carboxylic acid, excluding benzoyl or
- (iv) aralkyl;
- R.sub.2 is
- (i) hydrogen,
- (ii) acyclic or cyclic, saturated or unsaturated alkyl having 1-8 carbon atoms,
- (iii) oxygen- or nitrogen-containing 5- or 6-membered heterocyclic group,
- (iv) acyl derived from acyclo- or cyclo-aliphatic, aromatic or aromatic-aliphatic carboxylic acid, or
- (v) aralkyl;
- R.sub.3 and R.sub.4 are hydrogen or hydroxyl;
- R.sub.5 and R.sub.6 are hydroxyl;
- and
- R.sub.7 is methyl;
- provided that if R.sub.1 is anisoyl, then R.sub.3 and R.sub.4 are hydrogen.
13 more elements
Dependencies are inferred from the claim text.