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US 5,514,682 AGranted
Fused imidazole and triazole derivatives as 5-HT1 receptor agonists
AssigneeMerck Sharp & Dohme Corp.
InventorLeslie J. Street
Life of this patent
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Abstract
Compounds of formula (I) wherein F represents a Group of the formula (a) ; E represents a bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms; and the rest of the variables are defined in the specification are selective agonists of 5HT.sub.1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.
Claims9
A compound of formula I, or a pharmaceutically acceptable salt or prodrug thereof:
- ##STR24## wherein Q represents the residue of a six-membered aromatic or heteroaromatic nucleus containing zero, one or two nitrogen atoms;
- A.sup.1 represents hydrogen, hydrocarbon, a heterocyclic group, halogen, cyano, trifluoromethyl, --OR.sup.x, --SR.sup.x, --NR.sup.x R.sup.y, --NR.sup.x COR.sup.y, --NR.sup.x CO.sub.2 R.sup.y, --NR.sup.x SO.sub.2 R.sup.y, or --NR.sup.z CTNR.sup.x R.sup.y ;
- V represents nitrogen or C--A.sup.2 ;
- E represents a bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms;
- F represents a group of formula ##STR25## U represents nitrogen or C--R.sup.2 ;
- B represents oxygen, sulphur or N--R.sup.3 ;
- R.sup.1 represents --CH.sub.2 --CHR.sup.4 --NR.sup.6 R.sup.7 or a group of formula (i), (ii), (iii) or (iv):
- ##STR26## in which the broken line represents an optional chemical bond;
- A.sup.2, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently represent hydrogen or C.sub.1-6 alkyl;
- R.sup.x and R.sup.y independently represent hydrogen, hydrocarbon or a heterocyclic group, or R.sup.x and R.sup.y together represent a C.sub.2-6 alkylene group;
- R.sup.z represents hydrogen, hydrocarbon or a heterocyclic group;
- T represents oxygen, sulphur or a group of formula .dbd.N.G;
- and
- G represents hydrocarbon, a heterocyclic group or an electron-withdrawing group.
11 more elements
Dependencies are inferred from the claim text.