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US 5,514,670 AGranted
Submicron emulsions for delivery of peptides
AssigneePharmos Corporation
InventorsDoron Friedman, Joseph Schwarz, Shimon Amselem
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AssigneePharmos Corporation
InventorsDoron Friedman, Joseph Schwarz, Shimon Amselem
Estimating the term…
The present invention provides emulsions comprising a plurality of submicron particles, a bioactive peptide, and an aqueous continuous phase or that effect enhanced oral bioavailability of the peptide. Another aspect of the invention provides compositions and methods of administering peptides in an emulsion comprising a plurality of submicron particles, a mucoadhesive macromolecule, a bioactive peptide, and an aqueous continuous phase, which promotes absorption of the bioactive peptide through mucosal surfaces by achieving mucoadhesion of the emulsion particles. Mucous surfaces suitable for application of the emulsions of the present invention may include corneal, conjunctival, buccal, sublingual, nasal, vaginal, pulmonary, stomachic, intestinal, and rectal routes of administration.
A lipid-in-water emulsion for administration of a biologically active peptide, said emulsion comprising a plurality of submicron particles each having a hydrophobic core, a surfactant, a biologically active peptide, and an aqueous continuous phase.
A lipid-in-water emulsion for administration of a biologically active peptide, said emulsion comprising a plurality of submicron particles each having a hydrophobic core, a surfactant, an aqueous continuous phase and a mucoadhesive macromolecule;
A dehydrated emulsion for administration of a biologically active peptide, comprising a plurality of submicron particles each having a hydrophobic core, said biologically active peptide, and a surfactant, whereby a submicron lipid-in-water emulsion is generated when water is added to said dehydrated emulsion.
A method for administering a bioactive peptide comprising applying to a mucosal surface a lipid-in-water emulsion comprising a plurality of particles each having a hydrophobic core, a bioactive peptide, a surfactant, and an aqueous continuous phase.
Dependencies are inferred from the claim text.